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Updated: Apr 5, 2026

Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System
Published on: May 24, 2017
Acute inhalation of vaporized nicotine increases arterial pressure in young non-smokers: a pilot study
William H Cooke1, Anusheela Pokhrel2, Colin Dowling2
1Department of Kinesiology, Health, and Nutrition, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA. william.cooke@utsa.edu.
Purpose:
Electronic cigarettes are growing in popularity, but the physiological consequences of vaporized nicotine are unknown.
Methods:
Twenty healthy non-smokers inhaled vaporized nicotine and placebo (randomized).
Results:
Nicotine inhalation was associated with higher arterial pressures in the seated position, and increased arterial pressures in the head-up positions with no other effects on autonomic control.
Conclusions:
Our results show that vaporized nicotine inhalation is not innocuous. Longitudinal studies in otherwise healthy non-smokers should be conducted.
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