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Related Experiment Video

Updated: Apr 5, 2026

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation
06:04

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation

Published on: August 8, 2025

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Apical closure device for transapical valve procedures.

Enrico Ferrari1, Denis Berdajs2, Piergiorgio Tozzi3

  • 1Cardiac Surgery Unit, Cardiocentro Ticino, Lugano, Switzerland Cardiovascular Research Unit, University of Lausanne, Lausanne, Switzerland enricoferrari@bluewin.ch.

Interactive Cardiovascular and Thoracic Surgery
|August 13, 2015
PubMed
Summary
This summary is machine-generated.

A novel sutureless apical occluder effectively seals large transapical access sites in animal models. This device offers a promising, less invasive alternative for transapical valve procedures, reducing the need for sutures.

Keywords:
Closure devicePercutaneous heart proceduresTransapical valve replacementTranscatheter aortic valve replacement

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Last Updated: Apr 5, 2026

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Area of Science:

  • Cardiovascular Surgery
  • Medical Devices
  • Minimally Invasive Procedures

Background:

  • Transapical transcatheter valve procedures require apical sutures for closure.
  • Large-caliber devices complicate minimally invasive or thoracoscopic approaches.
  • Current methods for apical access site closure can be invasive.

Purpose of the Study:

  • To evaluate a new sutureless, self-expandable apical occluder for transapical access site closure.
  • To assess the device's efficacy in a minimally invasive setting using large introducer sheaths.
  • To determine the feasibility of sutureless closure in an animal model.

Main Methods:

  • Implantation of the sutureless apical occluder in six pigs via a median sternotomy.
  • Use of a 21-Fr introducer sheath (25 Fr outer diameter) for apical access.
  • Deployment of the occluder under fluoroscopic guidance and observation of bleeding and hemodynamics for 1 hour.

Main Results:

  • Successful deployment of six apical closure devices in pig hearts.
  • Immediate apical sealing with minimal blood loss (mean 16 ± 3.4 ml).
  • Stable hemodynamic parameters and no detected plug dislodgement during the study period.

Conclusions:

  • The sutureless self-expandable apical occluder effectively seals large apical access sites (20-35 Fr).
  • This device represents a step towards less invasive transapical valve procedures.
  • Further animal studies are warranted to confirm long-term safety and efficacy.