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Metallic Profile of Whole Blood and Plasma in a Series of 99 Healthy Children

Jean-Pierre Goullé1, Pascal Le Roux2, Mireille Castanet3

  • 1Laboratoire de Toxicologie, ABTE ToxEMAC EA 4651, Faculté de Médecine et de Pharmacie, 22 boulevard Gambetta, 76183 Rouen Cedex 1, France Laboratoire de Pharmacocinétique et de Toxicologie Cliniques, Groupe Hospitalier du Havre, BP 24, 76083 Le Havre Cedex, France jean-pierre.goulle@univ-rouen.fr.

Journal of Analytical Toxicology
|August 13, 2015
PubMed

Insights

This study establishes pediatric reference values for heavy metals in children using a novel ICP-MS method. The findings provide crucial data for assessing metal exposure and toxicity in pediatric populations.

Area of Science:

  • Environmental Science
  • Toxicology
  • Pediatrics

Background:

  • Heavy metal exposure poses significant risks, particularly to children's health.
  • Establishing pediatric reference values for metals is challenging due to limited blood sample requirements for conventional methods.
  • Existing elemental reference values for children are scarce in scientific literature.

Purpose of the Study:

  • To adapt and validate an inductively coupled plasma mass spectrometry (ICP-MS) method for multielemental analysis in pediatric blood and plasma.
  • To determine pediatric reference values for 25 elements in whole blood and 23 elements in plasma.
  • To compare elemental concentrations across different age groups in children and between children and adults.

Main Methods:

  • Utilized a validated inductively coupled plasma mass spectrometry (ICP-MS) technique requiring only 0.3 mL of whole blood or plasma.
  • Analyzed samples from 99 healthy children aged under 5 to under 18 years.
  • Quantified 25 elements in whole blood and 23 elements in plasma simultaneously.

Main Results:

  • Successfully established a pediatric elemental profile for whole blood and plasma.
  • Observed variations in metallic concentrations among different pediatric age groups.
  • Identified differences in metallic concentrations between pediatric and adult populations.

Conclusions:

  • The developed pediatric metallic profile is a valuable tool for clinical and forensic toxicology.
  • This method facilitates accurate assessment of environmental metal exposure in children.
  • The study provides essential data for understanding metal accumulation and toxicity in pediatric health.

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