Related Experiment Video

Updated: Apr 5, 2026

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

1.9K

Chronic Renal Insufficiency Cohort Study (CRIC): Overview and Summary of Selected Findings

Matthew Denker1, Suzanne Boyle1, Amanda H Anderson1

  • 1Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.

Clinical Journal of the American Society of Nephrology : CJASN
|August 13, 2015
PubMed

Insights

The Chronic Renal Insufficiency Cohort (CRIC) Study investigates chronic kidney disease (CKD) progression and cardiovascular risks in diverse populations. Findings inform understanding of CKD complications and outcomes in mild-to-moderate disease and older adults.

Area of Science:

  • Nephrology
  • Epidemiology
  • Cardiovascular Medicine

Background:

  • The Chronic Renal Insufficiency Cohort (CRIC) Study is a major U.S. multicenter, prospective research initiative.
  • It focuses on racially and ethnically diverse patients diagnosed with chronic kidney disease (CKD).
  • Initially aimed at identifying CKD progression predictors and cardiovascular disease (CVD) risks, it has become a broad national resource.

Purpose of the Study:

  • To identify novel predictors of CKD progression.
  • To elucidate the risk and manifestations of cardiovascular disease in individuals with CKD.
  • To investigate morbidity, mortality, and CKD burden in mild-to-moderate CKD and older populations.

Main Methods:

  • Prospective, multicenter cohort study design.
  • Enrollment of a diverse patient population with varying stages of CKD.
  • Longitudinal data collection on clinical outcomes, biomarkers, and patient-reported data.

Main Results:

  • The CRIC Study has generated over 90 publications.
  • Key findings address race/ethnicity, CKD progression, cognitive function, and cardiovascular outcomes.
  • The study has fostered collaborations and career development in nephrology.

Conclusions:

  • The CRIC Study is a vital national resource for understanding CKD.
  • Ongoing research continues to address critical questions in nephrology.
  • Findings enhance global understanding of CKD and its complications.

Keywords:
chronic kidney diseasechronic renal insufficiencycohort study

More Related Videos

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

24.5K
Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies10:38

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies

Published on: January 16, 2019

21.0K

Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
1.2K
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
627
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
1.2K
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
970
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
499
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
1.5K