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Kluyvera ascorbata infections in children: a case series
Eda Karadağ Öncel1, Yasemin Özsürekci1, Yakut Akyön2
1Department of Pediatrics, Division of Pediatric Infectious Diseases, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Turk Pediatri Arsivi
|August 13, 2015
Summary
Kluyvera ascorbata infections are rare but serious in children, causing conditions like sepsis and pyelonephritis. Prompt antimicrobial treatment led to good outcomes in all reported pediatric cases.
Area of Science:
- Microbiology
- Infectious Diseases
- Pediatrics
Background:
- Kluyvera is an emerging pathogen within the Enterobacteriaceae family.
- While rare, Kluyvera species can cause severe infections, particularly in pediatric patients.
- This study investigates the clinical significance of Kluyvera ascorbata in children at a single institution.
Observation:
- A retrospective analysis of clinical microbiology data from 2006 identified four cases of clinically significant Kluyvera ascorbata infections.
- The affected pediatric patients, aged seven months to 17 years, presented with sepsis, central venous catheter-associated bacteremia, pyelonephritis, and intra-abdominal collections.
- All patients received timely antimicrobial therapy guided by susceptibility testing.
Findings:
- Prompt and appropriate antimicrobial treatment resulted in favorable clinical responses in all four pediatric cases.
- Effective treatment options included third-generation cephalosporins, aminoglycosides, beta-lactam/beta-lactamase inhibitors, and carbapenems.
- No mortality or long-term sequelae were reported in this small cohort.
Implications:
- Kluyvera ascorbata represents a pathogen of increasing clinical importance in pediatric infectious diseases.
- Clinicians should maintain awareness of the potential spectrum of disease caused by K. ascorbata in children.
- Early recognition and susceptibility-guided therapy are crucial for successful management of K. ascorbata infections in pediatric populations.
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