Large Mid-Esophageal Granular Cell Tumor: Benign Versus Malignant.

Area of Science:

• Oncology
• Pathology
• Radiology

Background:

• Granular cell tumors (GCTs) are rare soft tissue neoplasms, typically benign.
• Malignant GCTs are exceptionally rare, accounting for only 2% of cases and originating from nervous tissue.

Observation:

• This report details a large esophageal granular cell tumor.
• The tumor exhibited benign histopathological features.
• Despite benign histology, the tumor metastasized to the liver.

Findings:

• Positron emission tomography-computerized tomography (PET-CT) revealed a standardized uptake value (SUV) in the liver lesion.
• The SUV was suggestive of a benign process, creating a discrepancy with the observed metastasis.

Implications:

• This case highlights a potential diagnostic challenge in interpreting PET-CT findings for metastatic GCTs.
• It underscores the importance of integrating histopathology with imaging findings for accurate diagnosis.
• Further research may be needed to understand imaging characteristics of metastatic GCTs with benign histology.