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Updated: Apr 5, 2026

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody mAb by Neutralizing TNF Using an In Vitro Bioanalytical Method
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Strategic internal covalent cross-linking of TNF produces a stable TNF trimer with improved TNFR2 signaling

Liqin Ban1, Willem Kuhtreiber1, John Butterworth1

  • 1Immunobiology Laboratory, Harvard Medical School and Massachusetts General Hospital, Boston, MA USA.

Molecular and Cellular Therapies
|August 13, 2015
PubMed
Abstract

Keywords:
Cell signalingTNFTNFR2Transmembrane TNFTrimerTumor necrosis factorTumor necrosis factor receptor

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