Related Experiment Video

Updated: Apr 5, 2026

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
07:09

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States

Published on: April 1, 2015

12.1K

Fibrinolytic Activity of Blood and its Determinants in Healthy Medical Students

Nazeem I Siddqui1, M Shoeb2, S Bose3

  • 1Professor, Department of Physiology, Sri Aurobindo Medical College & Post Graduate Institute , Indore, India .

Journal of Clinical and Diagnostic Research : JCDR
|August 13, 2015
PubMed

Insights

Gender, body mass index, and menstrual cycle phases significantly impact blood fibrinolytic activity. These factors influence clot breakdown and may affect risks for cardiovascular and thromboembolic diseases.

Area of Science:

  • Hematology
  • Physiology
  • Endocrinology

Background:

  • Reduced fibrinolytic activity prolongs blood clot breakdown time, increasing hypercoagulable states.
  • Low fibrinolytic activity is linked to higher risks of coronary artery disease, stroke, and thromboembolic events.

Purpose of the Study:

  • To investigate the influence of gender, diet, BMI, physical activity, and menstrual cycle on fibrinolytic activity in healthy individuals.
  • To identify key factors affecting blood clot lysis time in a young, healthy population.

Main Methods:

  • Cross-sectional study involving 206 healthy medical students (ages 17-23).
  • Collected data on anthropometrics, diet, physical activity, and menstrual history.
  • Measured fibrinolysis time using the Euglobulin Lysis Time (ELT) method on fasting venous blood samples.

Main Results:

  • Significant gender differences observed in mean fibrinolytic activity (p=0.002).
  • Fibrinolytic activity showed a significant correlation with Body Mass Index (BMI) (p=0.001) and menstrual cycle phases (p=0.004).
  • No significant relationship found between fibrinolytic activity and diet or physical activity (p>0.05).

Conclusions:

  • Gender, BMI, and menstrual cycle phase are significant determinants of blood fibrinolytic activity.
  • Hormonal fluctuations, endometrial factors, and PAI-I from adipocytes may explain these observed influences.
  • Findings highlight the complex interplay of physiological factors affecting hemostasis.
Abstract

Keywords:
Coronary artery diseaseFibrinolysis timeHypercoagulable statesMenstrual cycleStroke

More Related Videos

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

19.5K
Author Spotlight: Time and Cost-Effective Fibrinogen-PAGE for Fibrinogenolytic Studies04:36

Author Spotlight: Time and Cost-Effective Fibrinogen-PAGE for Fibrinogenolytic Studies

Published on: April 19, 2024

961

Related Concept Videos

Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
10.3K
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
2.4K
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
15.5K
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
1.2K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
770