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Updated: Apr 5, 2026
Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
Corneal Cross-Linking for Brittle Cornea Syndrome
Claude Kaufmann1, Gregor Schubiger, Michael A Thiel
1*Department of Ophthalmology, Lucerne Cantonal Hospital, Lucerne, Switzerland; and †Ethics Committee for Research on Humans, Department of Health, Lucerne, Switzerland.
Purpose:
To describe corneal cross-linking (CXL) as a treatment option for brittle cornea syndrome (BCS).
Methods:
Case report.
Results:
Ethical decision making enabled bilateral sequential transepithelial CXL in an 11-year-old girl with BCS. Postoperative courses were uneventful with a bilateral stromal demarcation line, unchanged corneal transparency, constant endothelial cell density, and stable topography 2 years after intervention.
Conclusions:
Modified CXL can safely be performed in patients with BCS. Ethical review may be helpful for interventions deviating from standard practice.
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