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Related Experiment Video

Updated: Apr 5, 2026

An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation
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Interplay between Static and Dynamic Energy Transfer in Biofunctional Upconversion Nanoplatforms.

Yadan Ding1,2, Fei Wu3, Youlin Zhang3

  • 1†Centre for Advanced Optoelectronic Functional Materials Research, Key Laboratory for UV Light-Emitting Materials and Technology of the Ministry of Education, Northeast Normal University, Changchun 130024, People's Republic of China.

The Journal of Physical Chemistry Letters
|August 13, 2015
PubMed
Summary

Optimizing energy transfer (ET) in upconversion nanoplatforms is crucial for biomedical uses. This study models shell thickness effects on dynamic and static ET, improving efficiency significantly.

Keywords:
Er3+/NaYF4Förster resonant energy transferNaYF4:Yb3+inner filter effectoptimal shell thicknessquantitative analysisreabsorptionupconversion

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Area of Science:

  • Nanotechnology
  • Biomedical Engineering
  • Materials Science

Background:

  • Upconversion nanoplatforms (UCNPs) are vital for bioimaging and therapy, but their efficiency relies on understanding energy transfer (ET) mechanisms.
  • Current optimization strategies often overlook the interplay between dynamic and static ET, assuming dynamic ET dominance.
  • Developing efficient UCNPs requires a quantitative model that considers both dynamic and static ET pathways.

Discussion:

  • This research quantitatively models the shell-thickness-dependent interplay between dynamic and static energy transfer in core-shell UCNPs.
  • The model was validated using a biofunctional nanoplatform comprising NaYF4:Er, Yb/NaYF4 upconversion nanoparticles (UCNPs) and Rose Bengal (RB) as an energy acceptor.
  • Analysis revealed that optimizing shell thickness can enhance dynamic ET by approximately 4-fold and static ET by approximately 9-fold compared to bare core UCNPs.

Key Insights:

  • A quantitative model elucidating the shell-thickness-dependent dynamic and static energy transfer in UCNPs has been developed.
  • Proper shell engineering significantly boosts both dynamic and static energy transfer pathways in UCNPs for enhanced performance.
  • The findings demonstrate a substantial improvement in energy transfer efficiency through controlled nanostructure design.

Outlook:

  • This work provides a foundational understanding for designing highly efficient energy transfer-based biofunctional nanoplatforms.
  • Future research can leverage this model to engineer novel UCNPs with tailored shell properties for advanced biomedical applications.
  • The quantitative insights will guide the development of next-generation upconversion systems for improved diagnostics and therapeutics.