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Related Concept Videos

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview01:19

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In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then...
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Inductively coupled plasma (ICP) is the most widely used plasma source in atomic emission spectroscopy (AES), also known as Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES). The ICP source, or torch, consists of three concentric quartz tubes with argon gas flowing through them. A spark from a Tesla coil initiates the ionization of argon, generating a high-temperature plasma.
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AES is a powerful analytical technique, especially effective when used with plasma sources, producing abundant spectra in characteristic emission lines. The Inductively Coupled Plasma (ICP), in particular, yields superior quantitative analytical data due to its high stability, low noise, low background, and minimal interferences under optimal experimental conditions. However, newer air-operated microwave sources are emerging as promising alternatives that could be more cost-effective than...
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Inductively coupled plasma–mass spectrometry (ICP–MS) is a highly selective and sensitive technique for accurate elemental analysis. Though the analysis of ICP–MS mass spectra is comparatively straightforward, it is affected by spectroscopic and non-spectroscopic interferences. Spectroscopic interferences arise when the plasma contains ionic species with an m/z value the same as the analyte ion. Spectroscopic interference can be categorized as isobaric, polyatomic ions, and...
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Higher molecular weight biomolecules are nonvolatile compounds that may decompose before ionizing or vaporizing during mass analysis with conventional electron impact ionization methods. Accordingly, electrospray ionization (ESI) is the favored method for vaporizing and ionizing biomolecules as it circumvents rapid fragmentation and enables the recording of mass signals for the entire biomolecule.
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In gas chromatography, different detectors are employed to meet specific analytical needs. These detectors are often categorized based on their detection mechanisms and the types of compounds they are best suited to analyze. Thermal Conductivity Detectors (TCD), Flame Ionization Detectors (FID), and Electron Capture Detectors (ECD) represent common categories, each with unique operating principles and applications. However, beyond these, several other detectors are designed for more specialized...
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Low-temperature plasma ionization differential ion mobility spectrometry.

Andriy Kuklya1, Carsten Engelhard2, Florian Uteschil1

  • 1Department of Instrumental Analytical Chemistry, University of Duisburg-Essen (UDE) , Universitätsstraße 5, 45141 Essen, Germany.

Analytical Chemistry
|August 13, 2015
PubMed
Summary

A novel low-temperature plasma (LTP) ionization source was coupled with differential ion mobility spectrometry (DMS) for rapid, on-site monitoring. This advancement shows promising analytical performance, comparable to existing methods, with reduced operational costs.

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Area of Science:

  • Analytical Chemistry
  • Plasma Physics
  • Spectrometry

Background:

  • Differential Ion Mobility Spectrometry (DMS) is valuable for rapid chemical analysis.
  • Existing DMS systems often require complex or costly ionization sources.
  • Miniaturization of DMS for on-site monitoring necessitates efficient and simple ionization.

Purpose of the Study:

  • To introduce and evaluate a low-temperature plasma (LTP) as a novel ionization source for DMS.
  • To investigate the impact of experimental parameters on LTP-DMS performance for aromatic compounds.
  • To assess the analytical capabilities of LTP-DMS in comparison to established ionization techniques.

Main Methods:

  • Coupling of a low-temperature plasma (LTP) ionization source with differential ion mobility spectrometry (DMS).
  • Investigation of discharge/carrier gas composition, flow rate, and applied voltage effects.
  • Analysis of six model aromatic compounds and comparison with atmospheric pressure photoionization (APPI) and atmospheric pressure chemical ionization (APCI) ((63)Ni).

Main Results:

  • LTP successfully served as an ionization source for DMS.
  • Reactant ion formation was dependent on gas composition; pure nitrogen yielded optimal analyte response.
  • Achieved limit of detection (LOD) values of 35–257 ng L⁻¹, competitive with traditional sources.
  • Demonstrated potential for helium-free operation, reducing costs for on-site monitoring.

Conclusions:

  • Low-temperature plasma (LTP) is a viable and promising ionization source for differential ion mobility spectrometry (DMS).
  • LTP-DMS offers competitive analytical performance and potential for miniaturized, on-site, and cost-effective monitoring applications.
  • The system's ability to operate without helium is a significant advantage for practical deployment.