[Effects of CCK-8 of hypothalamus on antral motility in rats]

Cholecystokinin-octapeptide (CCK-8) of 10 ng were injected into lateral hypothalamus (LH) and ventromedial hypothalamus (VMH) in conscious rats, both of which brought about inhibition of antral motility recorded by a strain gauge, the actions were partly antagonised by bilateral vagotomy, but blocked by intravenous infusion of atropine or regitine. It is suggested that both vagus and sympathetic nerves be involved in mediation of function of central CCK-8. In addition, the unit spontaneous discharges of neurons in vagal nuclei were attenuated while CCK-8 injected into LH. On the contrary, the antral motility was stimulated markedly by injection CCK-8-antiserum into LH, indicating that the endogenous CCK-8 in this area exercises a continuous restraint on antral motility in the basal state. CCK-8 cells both in LH and VMH were visualized by PAP method. It may be reasonable to refer this as the histological basis of the identical function on antral motility exercised by CCK-8 both in LH and VMH.