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Updated: Apr 5, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Primary renal extra-osseous osteosarcoma.

Kevin J Flynn¹, Hristos Z Kaimakliotis, Liang Cheng

¹Department of Urology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

The Canadian Journal of Urology

|August 13, 2015

Summary

This summary is machine-generated.

Primary renal extra-osseous osteosarcoma is a rare kidney cancer. Surgical resection offers a chance for survival, as demonstrated by a patient with no evidence of disease 30 months post-surgery.

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Area of Science:

Oncology
Nephrology
Pathology

Background:

Primary renal extra-osseous osteosarcoma is an exceptionally rare and aggressive kidney neoplasm, with limited documented cases.
This mesenchymal sarcoma, characterized by osteoid production without skeletal involvement, typically originates in the extremities but can occur in the kidney.
It is considered a distinct entity from osseous osteosarcoma, necessitating specific treatment considerations.

Observation:

A 77-year-old woman presented with gross hematuria.
Initial diagnosis was upper tract urothelial cell carcinoma.

Findings:

Pathologic analysis confirmed primary renal extra-osseous osteosarcoma.
The patient remains disease-free 30 months post-surgery.

Implications:

Highlights the importance of accurate diagnosis for this rare tumor.
Surgical resection is the primary treatment modality.
Emphasizes the potential for favorable outcomes with timely intervention.