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Updated: Apr 5, 2026

Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
Published on: September 29, 2015
[Preliminary clinical observation for platelet-rich fibrin in site preservation]
Binping Wang1, Pu Xu1, Xiuli Wang1
1Oral Implant Department of Stomatology, Affi liated Haikou Hospital, Xiangya School of Medicine, Central South University; Hainan Provincial Stomatology Center, Haikou 570208, China.
Objective:
To observe the clinical effect on site preservation with self platelet-rich fibrin (PRF) in posterior dental areas after extraction.
Methods:
Thirty patients who asked to extract posterior teeth and were ready for dental implantation were enrolled. PRF was implanted immediately in alveolar fossa after extraction. Cone beam computer tomography (CBCT) images were taken after 4-6 months and the changes in height and width of alveolar bone were observed.
Results:
There was no statistical difference in the height and width between the alveolar bone treated with PRF after the extraction of tooth and the bone condition before the extraction of tooth.
Conclusion:
The site preservative technology with PRF could maintain the mass of alveolar bone in posterior dental areas, which provide a better bone condition for later dental implantation.
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