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[Psoriatic osteopathy].

G Hein1, K Abendroth, A Müller

  • 1Klinik für Innere Medizin des Bereiches Medizin der Friedrich-Schiller-Universität Jena.

Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete
|November 15, 1989
PubMed
Summary
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Psoriasis and psoriatic arthritis patients show generalized "latent" osteopathy, characterized by increased bone turnover. This suggests a potential link to vitamin D deficiency and resistance, impacting bone health in these conditions.

Area of Science:

  • Endocrinology
  • Rheumatology
  • Dermatology

Context:

  • Psoriasis and psoriatic arthritis are chronic inflammatory conditions.
  • Osteopathy in psoriatic patients has been postulated but not fully elucidated.
  • Bone metabolism alterations are increasingly recognized in inflammatory diseases.

Purpose:

  • To investigate the presence and characteristics of generalized osteopathy in patients with psoriasis and psoriatic arthritis.
  • To assess serum calcium, alkaline phosphatase, and urinary hydroxyproline levels.
  • To histologically and morphometrically examine bone biopsies.

Summary:

  • The study examined 24 patients with psoriasis and 24 with psoriatic arthritis, measuring serum calcium, alkaline phosphatase, and urinary hydroxyproline.

Related Experiment Videos

  • Bone biopsies from 25 psoriatic arthritis and 10 psoriasis patients were analyzed.
  • Findings indicate a generalized
  • latent
  • osteopathy with high turnover remodeling in both psoriasis and psoriatic arthritis patients, without significant bone volume loss.

    • Impact:

    • Provides evidence for generalized osteopathy in psoriatic conditions.
    • Highlights increased bone turnover as a key feature.
    • Suggests latent vitamin D deficiency and D-hormone resistance as potential common pathogenic factors for both skin and bone manifestations.