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Updated: Apr 5, 2026

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
Published on: August 1, 2025
Safety and Toxicology of Cannabinoids
Jane Sachs1, Erin McGlade2, Deborah Yurgelun-Todd2
1Department of Psychiatry, University of Utah, 383 Colorow Drive, Salt Lake City, UT, 84108, USA. jane.sachs@utah.edu.
Abstract:
There is extensive research on the safety, toxicology, potency, and therapeutic potential of cannabis. However, uncertainty remains facilitating continued debate on medical and recreational cannabis policies at the state and federal levels. This review will include a brief description of cannabinoids and the endocannabinoid system; a summary of the acute and long-term effects of cannabis; and a discussion of the therapeutic potential of cannabis. The conclusions about safety and efficacy will then be compared with the current social and political climate to suggest future policy directions and general guidelines.
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