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[Association between body mass index and cardiovascular events in male elderly hypertensive patients]
Jinxia Zhang1, Zhihua Gong, Yingqing Feng
1Department of Cardiology, Guangzhou General Hospital of Guangzhou Command, Guangzhou 510010, China.
Insights
Higher body mass index (BMI) in elderly men with hypertension is linked to lower mortality. This 10-year study found overweight and obese hypertensive men had reduced risks of death and cardiovascular events compared to normal weight individuals.
Area of Science:
- Gerontology
- Cardiology
- Public Health
Background:
- Hypertension is a prevalent condition in elderly populations.
- The relationship between body mass index (BMI) and health outcomes in elderly hypertensive individuals requires further investigation.
Purpose of the Study:
- To examine the long-term association between body mass index (BMI) and cardiovascular events in elderly male hypertensive patients.
Main Methods:
- A prospective study included 839 elderly male hypertensive patients (>65 years).
- Participants were categorized into normal weight, overweight, and obese groups based on BMI.
- Follow-up was conducted yearly for 10 years to record all-cause death and cardiovascular events.
Main Results:
- Overweight and obese hypertensive men (BMI ≥ 24.0 kg/m²) exhibited significantly lower all-cause mortality compared to normal weight individuals (BMI < 24.0 kg/m²).
- Kaplan-Meier analysis indicated higher all-cause and cardiovascular mortality in the normal weight group.
- Cox regression revealed reduced risks for all-cause mortality and cardiovascular death in patients with BMI ≥ 24.0 kg/m².
Conclusions:
- The study observed an 'obesity paradox' in elderly male hypertensive patients.
- Higher BMI (≥ 24.0 kg/m²) was associated with lower mortality risks over a 10-year follow-up period.
Objective:
To observe the long-term relationship between body mass index (BMI) and cardiovascular events in male elderly hypertensive patients.
Methods:
A total of 839 male elderly (>65 years old) hypertensive patients were included in this prospective study. Baseline data were obtained on January 2004 and participants were followed up yearly till January 2014. Patients were divided into 3 groups according to their BMI: normal weight group (18.5 kg/m² ≤ BMI<24.0 kg/²), overweight group (24.0 kg/m² ≤ BMI<28.0 kg/m²), obese group (BMI ≥ 28.0 kg/m²). All-cause death and cardiovascular events were compared.
Results:
The average age of all 839 hypertension men was (75.4 ± 4.8) years at baseline. Baseline systolic blood pressure was (133.7 ± 14.6) mmHg (1 mmHg=0.133 kPa), diastolic blood pressure was (74.3 ± 9.3)mmHg. Baseline systolic and diastolic blood pressure was similar among the three groups. All 839 patients completed follow-up. There were 178 all-cause deaths, 54 cardiovascular deaths, 51 new/recurrent myocardial infarctions and 105 new/recurrent strokes during follow up. Incidence of all-cause mortality in overweight group (16.74%,72/430) was significantly lower than in normal weight group (27.01% (74/274), P<0.05). Kaplan-Meier curves showed the all-cause mortality and cardiovascular mortality were higher in normal weight group than in the other two groups. According to the Cox proportional hazards regression model, the risk of all-cause mortality (RR=0.867, 95% CI: 0.792-0.949) and cardiovascular death (RR=0.179, 95% CI : 0.05-0.645) in patients with a BMI ≥ 24.0 kg/m² were lower than in the group with BMI<24.0 kg/m².
Conclusion:
Obesity paradox phenomenon is observed in elderly male hypertensive patients in that higher BMI is associated with lower mortality risks in elderly male hypertensive patients during the 10 years follow-up.
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