Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

5.1K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
5.1K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

1.7K
1.7K
Brain Imaging01:14

Brain Imaging

956
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
956
PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

6.4K
The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
6.4K
Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

10.4K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
10.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Disseminating Geometric Figures for Architecture Education and Research Through a Direct Data Stream Between CAD Software and a Web Viewer.

IEEE computer graphics and applications·2026
Same author

Physical interaction with Ephrin B1 promotes CXCR4 intracellular localization and oncogenic potential.

Cellular and molecular life sciences : CMLS·2026
Same author

GPRASP1 deletion suppresses antinociceptive tolerance during chronic activation of delta opioid receptor in persistent pain.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

TR-FRET between engineered nanobodies reveals the existence of endogenous CXCR4 oligomers.

Communications biology·2025
Same author

Phospho-Tau Signature During Mitosis: AT8, p-T217 and p-S422 as Key Phospho-Epitopes.

Cells·2025
Same author

Acute ischemic stroke and reperfusion drive molecular immune-vascular activations detectable in peripheral blood.

Journal of neurointerventional surgery·2025

Related Experiment Video

Updated: Apr 5, 2026

Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation
09:52

Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation

Published on: February 23, 2020

10.0K

mTOR in Brain Physiology and Pathologies.

Joël Bockaert1, Philippe Marin1

  • 1Centre National de la Recherche Scientifique, UMR-5203, Institut de Génomique Fonctionnelle, Montpellier, France; Institut National de la Santé et de la Recherche Médicale U1191, Montpellier, France; and Université de Montpellier, UMR-5203, Montpellier, France.

Physiological Reviews
|August 14, 2015
PubMed
Summary
This summary is machine-generated.

The target of rapamycin (TOR) pathway, particularly mTOR, regulates vital cellular functions and brain activity. Its dual role in disease suggests mTORC1 inhibition or stimulation may treat neurological and psychiatric disorders.

More Related Videos

Analysis of Brain Mitochondria Using Serial Block-Face Scanning Electron Microscopy
07:47

Analysis of Brain Mitochondria Using Serial Block-Face Scanning Electron Microscopy

Published on: July 9, 2016

14.8K
Modeling Mitochondrial Disease Using Brain Organoids: A Focus on Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes
08:56

Modeling Mitochondrial Disease Using Brain Organoids: A Focus on Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes

Published on: October 10, 2025

887

Related Experiment Videos

Last Updated: Apr 5, 2026

Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation
09:52

Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation

Published on: February 23, 2020

10.0K
Analysis of Brain Mitochondria Using Serial Block-Face Scanning Electron Microscopy
07:47

Analysis of Brain Mitochondria Using Serial Block-Face Scanning Electron Microscopy

Published on: July 9, 2016

14.8K
Modeling Mitochondrial Disease Using Brain Organoids: A Focus on Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes
08:56

Modeling Mitochondrial Disease Using Brain Organoids: A Focus on Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes

Published on: October 10, 2025

887

Area of Science:

  • Cellular Biology
  • Neuroscience
  • Biochemistry

Background:

  • The target of rapamycin (TOR) pathway, including its mammalian ortholog mTOR, was identified through studies of the immunosuppressant rapamycin.
  • mTOR exists in two complexes, mTORC1 and mTORC2, influenced by nutrients, energy, growth factors, hormones, and neurotransmitters.

Purpose of the Study:

  • To explore the role of mTOR signaling in cellular functions and neurological processes.
  • To investigate the therapeutic potential of modulating mTOR signaling in various pathologies.

Main Methods:

  • The abstract does not specify methods.
  • Literature review and synthesis of preclinical and clinical findings.

Main Results:

  • mTOR governs fundamental cellular processes like protein synthesis, metabolism, and organelle biogenesis.
  • mTOR signaling impacts neuronal development, synaptic plasticity, memory, and cognition.
  • mTOR pathway deregulation is linked to neurological and psychiatric disorders.

Conclusions:

  • Inhibition of mTORC1 shows promise for epilepsy, cognitive impairment, and brain tumors.
  • Stimulation of mTORC1 may benefit depression and promote axonal regeneration.