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A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies
Published on: July 28, 2020
Significance of local treatment in patients with metastatic soft tissue sarcoma
Long Jiang1, Shanshan Jiang2, Yongbin Lin2
1Sun Yat-Sen University Cancer Center 651, Dongfeng Rd East, Guangzhou 510060, P. R. China ; Collaborative Innovation Center for Cancer Medicine 651, Dongfeng Rd East, Guangzhou 510060, P. R. China ; State Key Laboratory of Oncology in South China 651, Dongfeng Rd East, Guangzhou 510060, P. R. China ; University of California San Francisco, San Francisco, USA.
Abstract:
Metastatic soft tissue sarcomas (STS) represent enormous challenges to improve the low survival rate, which is almost the same as past 2 decades ago, although surgery, radiotherapy and radiofrequency ablation has been accepted in the treatment of metastatic STS. Moreover, STS varies between elderly and younger victims in the aspect of diagnoses, prognosis, and treatment strategies. In order to evaluate the role of local treatment in improving prognosis for patients with metastatic STS and select the proper candidates who will benefit from local therapy, a single-institution nearly 50-year experience were collected and reviewed. Finally, we found that local treatments could improve treatment response and survival, but overall survival advantage could not be seen in elderly patients. This conclusion from a single institution could serve as a basis for future prospective multi-institutional large-scale studies.
