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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
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Published on: September 9, 2012

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Acquired factor V inhibitor after exposure to topical human thrombin related to an otorhinolaryngological procedure

K Donohoe1, R Levine1,2

  • 1Hematology and Oncology, Lenox Hill Hospital, New York, NY, USA.

Journal of Thrombosis and Haemostasis : JTH
|August 14, 2015
PubMed

Acquired factor V (FV) inhibitors occur rarely and classically develop after exposure to bovine thrombin. The clinical presentation is variable, ranging from asymptomatic with incidental laboratory abnormalities to significant bleeding. With the development of human-derived thrombin agents, bovine thrombin is less frequently used. We report a case of an acquired FV inhibitor that developed in a patient after exposure to human thrombin used as a hemostatic agent during an otorhinolaryngology surgical procedure. Our review of the literature revealed only one prior reported case of FV inhibitor after exposure to human thrombin. Hematologists and surgeons should be aware of this rare, but potentially life-threatening, complication in the postprocedural setting.

Keywords:
autoantibodiesbleedingfactor Vhemorrhagerecombinant human thrombin

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