Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model01:09

Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model

917
Various dissolution theories provide insight into the factors that influence the dissolution rate. Danckwerts' Model suggests that turbulence, rather than a stagnant layer, characterizes the dissolution medium at the solid-liquid interface. In this model, the agitated solvent contains macroscopic packets that move to the interface via eddy currents, facilitating the absorption and delivery of the drug to the bulk solution. The regular replenishment of solvent packets maintains the...
917
Electrochemical Systems01:24

Electrochemical Systems

130
Electrochemical systems provide a fascinating insight into the dynamic interplay of charged species within various phases. One notable example is the interaction between a membrane permeable to K⁺ ions but not to Cl⁻ ions, separating an aqueous KCl solution from pure water. As K⁺ ions diffuse through the membrane, they generate net charges on each phase, leading to a potential difference between them.Similarly, when a piece of Zn is immersed in an aqueous ZnSO₄ solution,...
130
Liquid–Solid Solutions01:29

Liquid–Solid Solutions

97
The process of a solid dissolving in a liquid to form a solution is governed by the solubility limit, which is the maximum amount of the solid substance, or solute, that can be dissolved in a specific volume of the liquid or solvent. As the solute dissolves, it reaches a point where no more solute can be dissolved at a given temperature - this is known as the saturation point. However, if further solute is added and it manages to dissolve, the solution becomes supersaturated. Supersaturated...
97
Theories of Dissolution: Diffusion Layer Model01:15

Theories of Dissolution: Diffusion Layer Model

2.2K
Dissolution, the process by which drug particles dissolve in a solvent, is explained by the diffusion layer model, a theoretical framework that simulates the absorption of oral drugs and allows us to analyze experimental data.
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...
2.2K
Chemical Equilibria: Systematic Approach to Equilibrium Calculations01:21

Chemical Equilibria: Systematic Approach to Equilibrium Calculations

1.9K
Equilibrium calculations for systems involving multiple equilibria are often complex. For example, to calculate the solubility of a sparingly soluble salt in an aqueous solution in the presence of a common ion, one must consider all the equilibria in this solution. Calculations for these systems can be complicated and tedious, so a systematic approach with a series of steps is often helpful. The process is detailed below.
The first step is to identify all the chemical reactions involved, The...
1.9K
Ideal Solutions02:24

Ideal Solutions

23.3K
According to Raoult’s law, the partial vapor pressure of a solvent in a solution is equal or identical to the vapor pressure of the pure solvent multiplied by its mole fraction in the solution. However, Raoult's Law is only valid for ideal solutions. For a solution to be ideal, the solvent-solute interaction must be just as strong as a solvent-solvent or solute-solute interaction. This suggests that both the solute and the solvent would use the same amount of energy to escape to the...
23.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Proteome-scale quantification of the interactions driving condensate formation of intrinsically disordered proteins.

Nature communications·2026
Same author

Divergent effects of pathological α-synuclein truncations and mutations on phase separation.

Nature communications·2026
Same author

α-Synuclein overexpression increases the tropism of pre-formed fibrils and MSA-patient derived seeds towards oligodendroglia.

Acta neuropathologica communications·2026
Same author

Glucagon-Like Peptide-1 Receptor Agonists Inhibit the Initiation of Toxic Amyloid-β42 Aggregation.

Journal of the American Chemical Society·2026
Same author

Self-consistent analytical solutions to the Voorn-Overbeek model.

The Journal of chemical physics·2026
Same author

The amplification of α-synuclein amyloid fibrils.

Biochemical Society transactions·2026

Related Experiment Video

Updated: Apr 5, 2026

An Inverse Analysis Approach to the Characterization of Chemical Transport in Paints
08:42

An Inverse Analysis Approach to the Characterization of Chemical Transport in Paints

Published on: August 29, 2014

8.8K

Quantitative Analysis of Diffusive Reactions at the Solid-Liquid Interface in Finite Systems.

Thomas C T Michaels1, Alexander K Buell1, Eugene M Terentjev2

  • 1†Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.

The Journal of Physical Chemistry Letters
|August 14, 2015
PubMed
Summary

This study introduces a new model for reactions between dissolved particles and surfaces, enabling precise analysis of reaction kinetics and mass sensitivity for complex surfaces like proteins. This advances understanding in surface chemistry and material science.

Keywords:
Cottrell equationSauerbrey equationamyloid fibersdepletionmass sensitivityquartz crystal microbalance (QCM)surface

More Related Videos

The Diffusion of Passive Tracers in Laminar Shear Flow
08:01

The Diffusion of Passive Tracers in Laminar Shear Flow

Published on: May 1, 2018

9.2K
Analyzing Melts and Fluids from Ab Initio Molecular Dynamics Simulations with the UMD Package
06:37

Analyzing Melts and Fluids from Ab Initio Molecular Dynamics Simulations with the UMD Package

Published on: September 17, 2021

5.3K

Related Experiment Videos

Last Updated: Apr 5, 2026

An Inverse Analysis Approach to the Characterization of Chemical Transport in Paints
08:42

An Inverse Analysis Approach to the Characterization of Chemical Transport in Paints

Published on: August 29, 2014

8.8K
The Diffusion of Passive Tracers in Laminar Shear Flow
08:01

The Diffusion of Passive Tracers in Laminar Shear Flow

Published on: May 1, 2018

9.2K
Analyzing Melts and Fluids from Ab Initio Molecular Dynamics Simulations with the UMD Package
06:37

Analyzing Melts and Fluids from Ab Initio Molecular Dynamics Simulations with the UMD Package

Published on: September 17, 2021

5.3K

Area of Science:

  • Physical Chemistry
  • Surface Science
  • Biophysics

Background:

  • Reactions between surface-bound species and solution-phase partners are crucial in various scientific fields.
  • Existing integrated rate laws are limited to specific scenarios, hindering quantitative analysis.
  • Understanding these reactions is vital for fields like biosensing and materials science.

Purpose of the Study:

  • To develop a general analytical model for irreversible reactions between soluble particles and a surface in a finite volume.
  • To enable quantitative analysis of transient kinetics for surface-solution reactions.
  • To determine mass sensitivity coefficients for soft and rough surfaces.

Main Methods:

  • Development of a novel analytical model for reaction kinetics.
  • Application of the model to quartz crystal microbalance (QCM) experiments.
  • Analysis of protein aggregation kinetics under combined reaction-diffusion control.

Main Results:

  • An analytical expression was derived for the time dependence of surface-reaction kinetics.
  • The model successfully quantifies transient kinetics where both reaction and diffusion are significant.
  • Absolute mass sensitivity coefficients were determined for challenging soft and rough surfaces.

Conclusions:

  • The new model provides a powerful tool for analyzing surface-solution interactions.
  • It overcomes limitations of previous models, particularly for complex surface types.
  • This work has implications for accurate characterization in QCM and related surface-sensitive techniques.