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BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function

Xuetian Yue1, Yuhan Zhao1, Juan Liu1

  • 1Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, United States.

Elife
|August 14, 2015
PubMed
Summary

The Bcl-2 associated athanogene (BAG) family protein BAG2 promotes tumor growth by stabilizing mutant p53 (mutp53). BAG2 inhibits the degradation of mutp53, enhancing its tumor-promoting gain-of-function activities.

Keywords:
BAG2cell biologyhumanhuman biologymedicinemousemutant p53tumorigenesis

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