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[Nephrotic syndrome and B leukemia].

H Pacquement1, P Sinnassamy, E Quintana

  • 1Services d'Oncologie Pédiatrique, Institut Curie, Paris.

Archives Francaises De Pediatrie
|December 1, 1989
PubMed
Summary

A pediatric patient with Burkitt leukemia developed nephrotic syndrome during sepsis treatment. The condition resolved with leukemia treatment, showing a temporary link between infection, treatment, and kidney function in pediatric leukemia.

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Area of Science:

  • Pediatric Oncology
  • Nephrology
  • Infectious Diseases

Background:

  • A 14.5-year-old boy diagnosed with Burkitt leukemia had normal renal function prior to treatment.
  • Chemotherapy initiation followed the SFOP LMB 86 protocol.

Observation:

  • Following initial chemotherapy courses, the patient experienced Gram-negative sepsis, necessitating broad-spectrum antibiotics.
  • During sepsis, the patient developed nephrotic syndrome characterized by hypoalbuminemia, significant proteinuria, hypertension, and acute kidney injury.
  • Kidney biopsy revealed minimal glomerular changes and acute tubular lesions without immune deposits.

Findings:

  • The nephrotic syndrome and renal dysfunction resolved spontaneously within three weeks.
  • Resolution of nephrotic syndrome correlated with the successful treatment of Burkitt leukemia.

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Implications:

  • This case highlights a potential transient nephrotic syndrome associated with sepsis and chemotherapy in pediatric leukemia.
  • Early recognition and supportive care are crucial for managing renal complications during pediatric cancer treatment.
  • Further research may elucidate the specific mechanisms linking sepsis, chemotherapy, and acute kidney injury in this population.