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Extensive RPA2 hyperphosphorylation promotes apoptosis in response to DNA replication stress in CHK1 inhibited cells

Pedro Zuazua-Villar1, Anil Ganesh1, Geraldine Phear1

  • 1Molecular Oncology Unit, Department of Oncology, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield S10 2RX, UK.

Nucleic Acids Research
|August 15, 2015
PubMed
Summary

Replication protein A (RPA) hyperphosphorylation of RPA2 promotes cell death during replication stress when CHK1 is inhibited. This RPA2 hyperphosphorylation does not affect replication fork integrity but does reduce apoptosis when CHK1 is compromised.

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