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Biosynthesis and function of bacterial dialkylresorcinol compounds
Tim A Schöner1, Darko Kresovic1, Helge B Bode2,3
1Merck Stiftungsprofessur für Molekulare Biotechnologie, Fachbereich Biowissenschaften, Goethe Universität Frankfurt, Max-von-Laue-Str. 9, 60438, Frankfurt am Main, Germany.
Applied Microbiology and Biotechnology
|August 15, 2015
Summary
This review covers 40 years of research on bacterially produced dialkylresorcinols (DARs), focusing on their biosynthesis, gene clusters, and biological activities. It also explores ketosynthases (KS) and detection methods for these compounds.
Area of Science:
- Microbiology
- Biochemistry
- Natural Product Chemistry
Background:
- Dialkylresorcinols (DARs) are a class of compounds produced by bacteria.
- Their biosynthesis involves specific enzymes, including ketosynthases (KS).
- Research on DARs has spanned four decades, revealing diverse biological activities.
Purpose of the Study:
- To provide a comprehensive review of bacterially produced dialkylresorcinols (DARs).
- To summarize 40 years of DAR-related research.
- To discuss the enzymes, gene clusters, distribution, and biological activities of DARs.
Main Methods:
- Literature review of DAR research over the past 40 years.
- Analysis of ketosynthase (KS) enzyme functions, including DarB in DAR biosynthesis.
- Examination of DAR biosynthesis gene cluster (BGC) distribution across bacterial genomes.
Main Results:
- DAR biosynthesis gene clusters (BGCs) are found in over 100 bacterial genomes.
- The structures of biosynthetic products correlate with BGC distribution.
- Various biological activities of DARs have been identified.
Conclusions:
- Bacterial DARs represent a significant area of natural product research.
- Understanding DAR biosynthesis and distribution provides insights into bacterial metabolism.
- Further research into DARs' biological activities and detection methods is warranted.
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