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Updated: Jan 23, 2026

Author Spotlight: Unlocking Insights into the Immune Cell Landscape of Tumors
Published on: August 18, 2023
Making the case for chromatin profiling: a new tool to investigate the immune-regulatory landscape
Deborah R Winter1, Steffen Jung1, Ido Amit1
1Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel.
Abstract:
Recent technological advances have enabled researchers to accurately and efficiently assay the chromatin dynamics of scarce cell populations. In this Opinion article, we advocate the application of these technologies to central questions in immunology. Unlike changes to other molecular structures in the cell, chromatin features can reveal the past (developmental history), present (current activity) and future (potential response to challenges) of a given immune cell type; chromatin profiling is therefore an important new tool for studying the immune-regulatory networks of health and disease.
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