Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stress and Mental Health01:30

Stress and Mental Health

1.3K
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
1.3K
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

863
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
863
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

1.1K
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
1.1K
Depression: Overview01:18

Depression: Overview

1.2K
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
1.2K
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

680
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
680
Panic Disorder01:27

Panic Disorder

1.1K
Panic disorder is an anxiety disorder characterized by recurrent and sudden minutes-long episodes of intense fear, known as panic attacks. These attacks may feel like heart attacks and often happen without warning or a specific cause. They can include symptoms such as rapid heart rate, shortness of breath, chest pain, trembling, sweating, dizziness, and a sense of helplessness. During a panic attack, individuals may feel as though they are experiencing a heart attack or are in a...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Compounding Risks of Early Life Adversity and Couples' Later Life Conflicts in Biological Aging.

Biopsychosocial science and medicine·2026
Same author

Catalyzing cross-sectoral advocacy: Constructing the IMPACT theory for mobilizing arts in mental health policy.

Community health equity research & policy·2026
Same author

Omega-3 supplementation reduces perceived social isolation in a sex-dependent manner: Secondary analysis of an RCT.

Brain, behavior, and immunity·2026
Same author

Is a happy marriage a double-edged sword for biological aging? Preliminary evidence for the moderating role of couples' health behaviors.

Brain, behavior, and immunity·2026
Same author

Expanding access to perinatal trauma care: A dual-model evaluation of perinatal narrative exposure therapy training.

Psychological trauma : theory, research, practice and policy·2026
Same author

Early life abuse and neglect in breast cancer survivors: Associations with physical and psychological health throughout diagnosis and survivorship.

Journal of traumatic stress·2026

Related Experiment Video

Updated: Apr 5, 2026

A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice
05:28

A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice

Published on: May 15, 2019

23.9K

Sex Differences in Depression: Does Inflammation Play a Role?

Heather M Derry1, Avelina C Padin, Jennifer L Kuo

  • 1Institute for Behavioral Medicine Research, The Ohio State University College of Medicine, Columbus, OH, USA.

Current Psychiatry Reports
|August 15, 2015
PubMed
Summary

Women are more prone to depression due to a stronger link between inflammation and mood changes. This review explores the inflammation-depression connection, particularly in women, highlighting factors increasing their vulnerability.

More Related Videos

Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice
07:15

Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice

Published on: March 15, 2024

3.0K
An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

23.7K

Related Experiment Videos

Last Updated: Apr 5, 2026

A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice
05:28

A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice

Published on: May 15, 2019

23.9K
Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice
07:15

Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice

Published on: March 15, 2024

3.0K
An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

23.7K

Area of Science:

  • Neuroscience
  • Immunology
  • Psychiatry

Background:

  • Depression affects women more than men globally.
  • Inflammation is a key factor in depression onset and consequences.
  • Women exhibit higher inflammation levels and autoimmune disease risk than men.

Purpose of the Study:

  • To review the bidirectional relationship between inflammation and depression.
  • To explore why this link is particularly relevant for women's mental health.
  • To understand sex differences in depression etiology and treatment.

Main Methods:

  • Literature review examining studies on inflammation, depression, and sex differences.
  • Analysis of factors influencing inflammation and depression vulnerability in women.
  • Exploration of mood and behavioral responses to inflammation in women versus men.

Main Results:

  • Women show greater vulnerability to inflammation-induced mood changes, like loneliness.
  • Factors such as prior depression, obesity, and stress disproportionately increase inflammation in women.
  • Relationship distress and obesity are more strongly linked to inflammation in women, elevating depression risk.

Conclusions:

  • Women's heightened susceptibility to inflammation contributes to sex differences in depression.
  • Understanding the inflammation-depression link is crucial for women's mental health.
  • Targeting inflammation may offer effective depression treatment strategies for women.