Draft Genome Sequence of Neisseria gonorrhoeae Sequence Type 1407, a Multidrug-Resistant Clinical Isolate
A Anselmo1, A Ciammaruconi1, A Carannante2
1Army Medical and Veterinary Research Center, Rome, Italy.
Genome Announcements
|August 15, 2015
Summary
Drug-resistant gonorrhea poses a global health threat. This study details the genome sequence of a multidrug-resistant Neisseria gonorrhoeae strain, ST-1407, identified in Italy, contributing to understanding antimicrobial resistance.
Area of Science:
- Microbiology
- Genomics
- Infectious Diseases
Background:
- Neisseria gonorrhoeae is a significant cause of sexually transmitted infections.
- The emergence of antibiotic-resistant strains, particularly cefixime-resistant Neisseria gonorrhoeae (CRNG), poses a serious public health risk, potentially leading to untreatable gonorrhea.
- Sequence type 1407 (ST-1407) has been identified globally as a concerning lineage of resistant gonococci.
Purpose of the Study:
- To present the complete genome sequence of a specific multidrug-resistant Neisseria gonorrhoeae strain, G2891.
- To characterize strain G2891, which belongs to the globally relevant ST-1407 lineage.
- To contribute genomic data for understanding the evolution and spread of gonorrhea antimicrobial resistance.
Main Methods:
- Whole-genome sequencing of Neisseria gonorrhoeae strain G2891.
- Bioinformatic analysis of the obtained genome sequence.
- Identification of antimicrobial resistance genes and phylogenetic placement within Neisseria gonorrhoeae population structures.
Main Results:
- The genome sequence of Neisseria gonorrhoeae strain G2891 was successfully determined.
- Strain G2891 was confirmed as belonging to sequence type 1407 (ST-1407).
- The isolate exhibited multidrug resistance characteristics, consistent with other ST-1407 strains.
Conclusions:
- The genomic data of strain G2891 provides valuable insights into the genetic makeup of multidrug-resistant Neisseria gonorrhoeae.
- This finding supports the global surveillance of ST-1407 and other resistant gonococcal strains.
- Understanding the genomics of resistant strains is crucial for developing effective treatment and control strategies against gonorrhea.
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