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Related Concept Videos

Multiple Comparison Tests01:13

Multiple Comparison Tests

4.6K
Multiple comparison test, abbreviated as MCT, is a post hoc analysis generally performed after comparing multiple samples with one or more tests. An MCT will help identify a significantly different sample among multiple samples or a factor among multiple factors.
It would be easy to compare two samples using a significance alpha level of 0.05. In other words, there is only one sample pair to be compared. However, it would be difficult to identify a significantly different sample if the number...
4.6K

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Related Experiment Video

Updated: Apr 5, 2026

A Protocol of Manual Tests to Measure Sensation and Pain in Humans
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CPM Test-Retest Reliability: "Standard" vs "Single Test-Stimulus" Protocols.

Yelena Granovsky1,2, Adi Miller-Barmak2, Oren Goldstein2

  • 1*Department of Neurology, Rambam Health Care Campus y_granovsky@rambam.health.gov.il.

Pain Medicine (Malden, Mass.)
|August 15, 2015
PubMed
Summary
This summary is machine-generated.

The single test-stimulus conditioned pain modulation (STS-CPM) protocol demonstrated superior reliability for assessing pain modulation mechanisms. This finding supports its potential clinical utility in predicting pain and analgesic responses.

Keywords:
Conditioned Pain ModulationHeat PainInterclass CorrelationReliability

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Area of Science:

  • Neuroscience
  • Pain Research
  • Clinical Pain Assessment

Background:

  • Conditioned pain modulation (CPM) is crucial for understanding pain inhibitory mechanisms and predicting analgesic efficacy.
  • Reliability estimates of CPM protocols are needed to translate this paradigm into a clinical tool.

Purpose of the Study:

  • To estimate the intersession reliability of different CPM protocols.
  • To identify the most reliable CPM protocol for clinical application.

Main Methods:

  • Two studies involving 65 healthy young subjects assessed test-retest reliability of CPM protocols within 3-7 days.
  • Protocols included Bath-Thermode, Two-Thermodes, and a novel single test-stimulus CPM (STS-CPM).

Main Results:

  • The STS-CPM protocol exhibited superior reliability (ICC2,1 = 0.59) compared to Bath-Thermode (ICC2,1 = 0.34) and Two-Thermodes (ICC2,1 = 0.21).
  • Hand immersion conditioning pain showed higher reliability (ICC2,1 = 0.76) than thermode pain (ICC2,1 = 0.16).
  • STS-CPM demonstrated fair reliability for conditioned test-stimulus pain (ICC2,1 = 0.43).

Conclusions:

  • The newly developed STS-CPM paradigm is more reliable than previously tested protocols.
  • Further investigation into the clinical relevance of STS-CPM is warranted.
  • Factors like large conditioning stimulus contact size and single test-stimulus administration may enhance CPM reliability.