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Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag
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FGF23 and Phosphate Wasting Disorders.

Xianglan Huang1, Yan Jiang1, Weibo Xia1

  • 1Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences , Shuaifuyuan No. 1, Wangfujing, Dongcheng District, Beijing 100730, China.

Bone Research
|August 15, 2015
PubMed
Summary
This summary is machine-generated.

Fibroblast growth factor 23 (FGF23) regulates phosphate and bone health by linking the intestine, bone, and kidney. Abnormal FGF23 levels cause detrimental phosphate imbalances, impacting human health.

Keywords:
ADHRARHRDMP-1ENSFGF23KlothoMcCune Albright syndromeNFOGDPHEXXLHhypophosphatemic rickets

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Area of Science:

  • Endocrinology
  • Bone Biology
  • Mineral Metabolism

Background:

  • Phosphate homeostasis was historically attributed to parathyroid hormone and 1,25(OH)2D.
  • The discovery of fibroblast growth factor 23 (FGF23) has significantly advanced understanding of phosphate regulation and bone mineralization.
  • FGF23 acts as a crucial link between the intestine, bone, and kidney in maintaining phosphate balance.

Purpose of the Study:

  • To review the pathophysiology of FGF23.
  • To discuss hyper-FGF23 related renal phosphate wasting disorders.
  • To explore the complex mechanisms of phosphate homeostasis and bone mineralization.

Main Methods:

  • Literature review of FGF23.
  • Analysis of genetic and acquired abnormalities in FGF23.
  • Discussion of FGF23's role in phosphate reabsorption and calcitriol production.

Main Results:

  • FGF23, secreted by bone cells, regulates kidney phosphate handling and calcitriol production.
  • Abnormal FGF23 levels lead to either hypophosphatemia (hyper-FGF23) or hyperphosphatemia (hypo-FGF23).
  • Both hyper-FGF23 and hypo-FGF23 conditions are detrimental to human health.

Conclusions:

  • FGF23 is central to phosphate homeostasis and bone health.
  • Disorders of FGF23 present significant clinical challenges.
  • Further research is needed to fully elucidate the complex mechanisms of phosphate homeostasis and bone mineralization.