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INTERMITTENT DEGRADATION AND SCHIZOTYPY.

Matthew W Roché1, Steven M Silverstein2, Mark F Lenzenweger3

  • 1Department of Psychology, Binghamton University, State University of New York, Binghamton, NY 13902-6000.

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Intermittent degradation, transient performance disruptions, is linked to positive and disorganized schizotypy, not negative schizotypy or psychological states. This suggests it may be an endophenotypic marker for schizophrenia liability.

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Area of Science:

  • Cognitive Psychology
  • Psychiatry
  • Neuroscience

Background:

  • Intermittent degradation, characterized by temporary performance impairments, is frequently observed in schizophrenia patients.
  • It remains unclear if intermittent degradation is associated with schizotypy, the liability for schizophrenia.
  • The specificity of intermittent degradation to schizotypy requires investigation.

Purpose of the Study:

  • To determine if intermittent degradation is associated with schizotypy.
  • To examine the specificity of intermittent degradation to schizotypy versus other psychological states.
  • To explore intermittent degradation as a potential endophenotypic marker for schizophrenia.

Main Methods:

  • 92 undergraduates completed schizotypy and psychological state questionnaires.
  • Reaction times were recorded during questionnaire completion.
  • Intermittent degradation was quantified by reaction times exceeding three standard deviations from the mean, controlling for item processing load.

Main Results:

  • Intermittent degradation scores positively correlated with measures of positive and disorganized schizotypy.
  • No significant association was found between intermittent degradation and negative schizotypy.
  • Intermittent degradation was unrelated to psychological state variables like anxiety and depression.

Conclusions:

  • Intermittent degradation is specifically associated with certain facets of schizotypy.
  • This phenomenon may be a derivative of schizotypy.
  • Intermittent degradation shows potential as an endophenotypic marker for schizophrenia liability, warranting further research.