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Related Concept Videos

Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

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Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
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Local Anesthetics: Clinical Application as Spinal Anesthesia01:11

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Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
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Related Experiment Video

Updated: Apr 5, 2026

Whole Body Vibration Methods with Survivors of Polio
04:16

Whole Body Vibration Methods with Survivors of Polio

Published on: October 17, 2018

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Anesthesia and Poliomyelitis: A Matched Cohort Study.

Luke W Van Alstine1, Paul W Gunn, Darrell R Schroeder

  • 1From the Departments of *Anesthesiology, †Biomedical Statistics and Informatics, and ‡Neurology, Mayo Clinic, Rochester, Minnesota.

Anesthesia and Analgesia
|August 15, 2015
PubMed
Summary

Poliomyelitis survivors undergoing surgery show no increased risk of perioperative pulmonary complications. This study found similar outcomes in polio patients and matched controls, suggesting safe anesthetic management.

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Last Updated: Apr 5, 2026

Whole Body Vibration Methods with Survivors of Polio
04:16

Whole Body Vibration Methods with Survivors of Polio

Published on: October 17, 2018

9.3K

Area of Science:

  • Anesthesiology
  • Infectious Diseases
  • Public Health

Background:

  • Poliomyelitis, a viral disease, has a declining but not eradicated incidence, leaving many survivors.
  • Anesthetic management for polio survivors is understudied, relying mainly on anecdotal evidence.
  • This study aimed to characterize anesthetic implications and risks for polio survivors.

Purpose of the Study:

  • To investigate the perioperative anesthetic risks for poliomyelitis survivors.
  • To compare pulmonary complication rates between polio survivors and matched controls undergoing major surgery.
  • To identify potential challenges in anesthetic management for this patient population.

Main Methods:

  • A retrospective, matched cohort study design.
  • Identified 100 polio survivors who underwent major surgery between 2005-2009.
  • Matched each case with two controls based on age, sex, and surgical procedure.

Main Results:

  • No significant differences in pain scores, PACU/ICU admissions, or extubation locations were observed.
  • Pulmonary complication rates were similar between polio survivors (17%) and controls (14%), with an odds ratio of 1.5 (P=0.33).
  • Subset analysis of patients with persistent neurologic deficits also showed no significant difference in pulmonary complications.

Conclusions:

  • Poliomyelitis survivors do not appear to have an increased risk of perioperative pulmonary complications.
  • Anesthetic management for polio survivors is comparable to the general surgical population.
  • While risks are not significantly elevated, an odds ratio up to 3.3-fold warrants consideration.