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Frequency and Severity of Adverse Drug Events by Medication Classes: The JADE Study
Mio Sakuma, Yuko Kanemoto1, Akari Furuse1
1English, Faculty of Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
Journal of Patient Safety
|August 15, 2015
Summary
High-risk medications causing adverse drug events (ADEs) were identified. Frequent ADEs from antibiotics did not always correlate with severity, highlighting the need for careful drug risk assessment in hospitalized patients.
Area of Science:
- Clinical Pharmacology
- Patient Safety
- Drug Risk Management
Background:
- Adverse drug events (ADEs) pose a significant challenge in healthcare.
- Identifying high-risk medications is crucial for improving patient safety.
- Understanding the frequency and severity of ADEs across different drug classes is essential.
Purpose of the Study:
- To categorize high-risk medication classes based on the frequency and severity of associated ADEs.
- To analyze ADE profiles in hospitalized adult patients.
Main Methods:
- Prospective cohort study (JADE study) involving 3459 adult patients.
- Investigation of ADEs and prescribed medications.
- Calculation of ADE rates per medication class based on patient numbers.
Main Results:
- Antibiotics were most frequently associated with ADEs (31 per 100 patients).
- In older adults, corticosteroids, anticonvulsants, laxatives, NSAIDs, and antipsychotics were frequent ADE culprits after antibiotics.
- In younger adults, antibiotics were followed by laxatives, lipid-lowering agents, anticonvulsants, and corticosteroids.
- Cardiovascular agents caused fatal/life-threatening ADEs in 46% of elderly patients; antihypertensives were most frequent in younger patients (25%).
Conclusions:
- Medication classes frequently linked to ADEs do not always produce severe events.
- Risk stratification of medications requires consideration of both frequency and severity of ADEs.
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