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Relationship between antidepressant prescription and breast cancer: a population based study in Taiwan
Vincent Chin-Hung Chen1,2,3,4, Yin-To Liao1,2, Dah-Cherng Yeh5
1Department of Psychiatry, Chung Shan Medical University Hospital, Taichung, Taiwan.
Objective:
To investigate the association between antidepressant prescription and breast cancer.
Methods:
The National Health Research Institute in Taiwan provided a database of 1 000 000 random subjects for this study. We identified 14 737 new antidepressant female users who were more than 15 years old during 1999-2005 with at least 10 prescriptions and one year exposure to an antidepressant. These were matched 1:1 by age and residence to non-antidepressant users from the same database to compare the risk of breast cancer.
Results:
In a model adjusted by age, residence, insurance amount, and depressive disorder, antidepressant prescription was not associated with breast cancer risk. This held true for both selective serotonin re-uptake inhibitors (SSRIs) and tricyclic antidepressants.
Conclusions:
There was no evidence for an association between antidepressant prescription and the risk of breast cancer. Copyright © 2015 John Wiley & Sons, Ltd.
