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Installing multifunctionality on titanium with RGD-decorated polyurethane-polyurea roxithromycin loaded
Pau Rocas1, Mireia Hoyos-Nogués2,3, Josep Rocas4
1Institute for Research in Biomedicine (IRB Barcelona), 08028, Barcelona, Spain.
Advanced Healthcare Materials
|August 15, 2015
Abstract:
A novel class of polyurethane-polyurea nanoparticles (PUUa NPs) to install multifunctionality on biomaterials is presented. Biofunctionalization of titanium with roxithromycin loaded RGD-decorated PUUa NPs results in an outstanding improvement of osteoblast adhesion and strong suppression of bacterial attachment. This strategy represents a powerful approach to enhance the osseointegration of implant materials.
