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Related Experiment Video

Updated: Apr 5, 2026

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
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Intracranial pressure and glaucoma.

Timothy J McCulley1, Jessica R Chang, W Jordan Piluek

  • 1The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Journal of Neuro-Ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society
|August 15, 2015
PubMed
Summary

Intracranial pressure (ICP) affects the optic nerve, potentially influencing glaucoma development. This review examines the evidence linking ICP to glaucoma pathophysiology and its role as a risk factor.

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Area of Science:

  • Ophthalmology
  • Neurology

Background:

  • Intracranial pressure (ICP) significantly impacts optic nerve health.
  • Elevated ICP can cause optic disc edema and affect blood flow.
  • Orbital deformation is also linked to ICP fluctuations.

Purpose of the Study:

  • To explore the relationship between ICP and ocular structures.
  • To review the hypothesized connections between ICP and glaucoma.
  • To assess the current evidence for ICP as a glaucoma risk factor.

Main Methods:

  • Literature review of studies investigating ICP and glaucoma.
  • Analysis of physiological mechanisms linking ICP to optic nerve damage.
  • Synthesis of evidence supporting or refuting ICP's role in glaucoma.

Main Results:

  • ICP influences optic nerve structure, blood supply, and axonal transport.
  • Evidence suggests a plausible link between ICP changes and glaucoma.
  • Further research is needed to confirm ICP as a definitive glaucoma risk factor.

Conclusions:

  • ICP is a critical factor in optic nerve pathophysiology.
  • The role of ICP in glaucoma requires continued investigation.
  • Understanding ICP's impact may lead to new glaucoma management strategies.