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Updated: Apr 5, 2026
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
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Smoking and risk for psoriasis: a population-based twin study
Ann Sophie Lønnberg1, Lone Skov1, Axel Skytthe2
1Department of Dermato-Allergology, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
International Journal of Dermatology
|August 16, 2015
Summary
Smoking and psoriasis share genetic factors. Tobacco consumption and childhood environmental tobacco smoke (ETS) exposure significantly increase psoriasis risk, indicating a strong link between these conditions.
Area of Science:
- Dermatology
- Genetics
- Epidemiology
Background:
- Smoking is a known risk factor for psoriasis.
- Both psoriasis and smoking have a genetic component.
- Limited twin studies exist on the association between psoriasis and smoking.
Purpose of the Study:
- To investigate the association between smoking habits and psoriasis.
- To explore the role of genetic and environmental factors in the smoking-psoriasis link using twin modeling.
Main Methods:
- Data from 34,781 twins (aged 20-71) from the Danish Twin Registry were analyzed.
- Co-twin control analysis was performed on 1700 twin pairs discordant for smoking history.
- Classical twin modeling estimated genetic and environmental correlations.
Main Results:
- Psoriasis risk increased with age group and childhood environmental tobacco smoke (ETS) exposure.
- Smokers with >5 pack-years had substantially higher psoriasis risk, even after adjustments.
- Genetic factors explained 20% of the correlation between smoking and psoriasis.
Conclusions:
- Tobacco consumption and childhood ETS are significantly associated with psoriasis.
- Shared genetic factors contribute to the link between smoking and psoriasis.
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