Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Adrenergic Agonists: Indirect-Acting Agents01:25

Adrenergic Agonists: Indirect-Acting Agents

3.0K
Indirect-acting adrenergic agonists potentiate the effects of endogenous catecholamines through different mechanisms without directly binding to adrenoceptors.
One mechanism involves depleting stored catecholamines by displacing them from synaptic vesicles. These agents, known as "displacers," are transported into vesicles at the expense of noradrenaline. Examples include amphetamine and tyramine, which lack a catechol moiety, resulting in prolonged action, improved oral...
3.0K
Drugs Acting on Autonomic Ganglia: Stimulants01:23

Drugs Acting on Autonomic Ganglia: Stimulants

2.3K

Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating...
2.3K
Drugs Affecting Neurotransmitter Release or Uptake01:21

Drugs Affecting Neurotransmitter Release or Uptake

1.8K
Certain drugs can affect how neurotransmitters called catecholamines, are released or taken back up in the adrenergic neuron. They can have different effects on the body's sympathetic transmission. Reserpine, a natural compound found in the Rauwolfia shrub, blocks a transporter called vesicular monoamine transporter (VMAT), which leads to a buildup of catecholamines in the cell and reduces sympathetic transmission. Another drug called guanethidine works in multiple ways, including blocking...
1.8K
Sympathetic Signaling01:31

Sympathetic Signaling

3.5K
Sympathetic signaling, a vital part of the autonomic nervous system, plays a crucial role in mobilizing the body's resources in response to stress or emergencies. It involves the transmission of nerve impulses from sympathetic preganglionic fibers to postganglionic fibers. This results in the release of specific neurotransmitters and activation of adrenergic receptors.
Sympathetic preganglionic fibers release the neurotransmitter acetylcholine (ACh) onto the ganglionic neurons in the...
3.5K
Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

70.6K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
70.6K
Indirect-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship01:29

Indirect-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship

1.1K
Indirect-acting cholinergic agonists are agents that interact with the acetylcholinesterase enzyme in the synaptic cleft, preventing the breakdown of acetylcholine into choline and acetate. Consequently, the concentration of acetylcholine in the synaptic cleft increases. These agonists can be classified into reversible and irreversible inhibitors based on their duration of action.
Reversible inhibitors display short to medium durations of action. Short-acting agents include simple alcohols with...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cholecystokinin-expressing neurons of the ventromedial hypothalamic nucleus control energy homeostasis.

Frontiers in cellular neuroscience·2024
Same author

Higher-order thalamocortical circuits are specified by embryonic cortical progenitor types in the mouse brain.

Cell reports·2024
Same author

The neurophysiological basis of stress and anxiety - comparing neuronal diversity in the bed nucleus of the stria terminalis (BNST) across species.

Frontiers in cellular neuroscience·2023
Same author

Combining Whole-Cell Patch-Clamp Recordings with Single-Cell RNA Sequencing.

Methods in molecular biology (Clifton, N.J.)·2020
Same author

Embryonic progenitor pools generate diversity in fine-scale excitatory cortical subnetworks.

Nature communications·2019
Same author

Dynamic postnatal development of the cellular and circuit properties of striatal D1 and D2 spiny projection neurons.

The Journal of physiology·2019

Related Experiment Video

Updated: Apr 5, 2026

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice
08:27

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice

Published on: March 11, 2020

6.7K

Histamine and the striatum.

J Paul Bolam1, Tommas J Ellender1

  • 1Department of Pharmacology, MRC Brain Network Dynamics Unit, Mansfield Road, OX1 3TH Oxford, United Kingdom.

Neuropharmacology
|August 16, 2015
PubMed
Summary

Histamine, a brain neuromodulator, influences basal ganglia circuits, particularly the striatum. Dysfunction in these pathways is linked to neurological disorders like Tourette

Area of Science:

  • Neuroscience
  • Neuromodulation
  • Neuropharmacology

Background:

  • Histamine is a key neuromodulator released during wakefulness.
  • Abundant histamine receptors suggest widespread neural circuit control.
  • The precise role of histamine in many brain circuits remains unclear.

Purpose of the Study:

  • To review evidence of histaminergic modulation in basal ganglia circuitry.
  • To examine the striatum's role as a primary input nucleus.
  • To discuss histaminergic dysfunction in basal ganglia disorders.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of histaminergic modulation in basal ganglia.
  • Examination of histaminergic dysfunction in neurological diseases.
Keywords:
Basal gangliaHistamineParkinson's diseaseStriatumTourette's syndrome

More Related Videos

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area
09:54

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area

Published on: August 10, 2012

26.7K
A Plate-Based Assay for the Measurement of Endogenous Monoamine Release in Acute Brain Slices
07:56

A Plate-Based Assay for the Measurement of Endogenous Monoamine Release in Acute Brain Slices

Published on: August 11, 2021

3.9K

Related Experiment Videos

Last Updated: Apr 5, 2026

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice
08:27

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice

Published on: March 11, 2020

6.7K
Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area
09:54

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area

Published on: August 10, 2012

26.7K
A Plate-Based Assay for the Measurement of Endogenous Monoamine Release in Acute Brain Slices
07:56

A Plate-Based Assay for the Measurement of Endogenous Monoamine Release in Acute Brain Slices

Published on: August 11, 2021

3.9K

Main Results:

  • Histamine significantly modulates basal ganglia activity and behavior.
  • Histaminergic dysfunction is implicated in Parkinson's disease and Tourette's syndrome.
  • The striatum is a key site for histaminergic influence.

Conclusions:

  • Histamine plays a central role in basal ganglia function.
  • Histamine represents a potential therapeutic target for basal ganglia disorders.
  • Further research into histaminergic pathways is warranted.