Related Experiment Video

Updated: Apr 5, 2026

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

9.3K

MAP Kinase Cascades in Antigen Receptor Signaling and Physiology

Tomoharu Yasuda1

  • 1Immune Regulation and Cancer, Max Delbrück Center for Molecular Medicine, Robert-Rössle Str 10, 13125, Berlin, Germany. tomoharu.yasuda@mdc-berlin.de.

Current Topics in Microbiology and Immunology
|August 16, 2015
PubMed

Insights

Mitogen-activated protein kinases (MAPKs) are crucial signaling molecules that control cell functions like growth and death. These pathways are vital for B cell immunity and have distinct, non-overlapping roles.

Area of Science:

  • Cellular signaling and immunology

Background:

  • Mitogen-activated protein kinases (MAPKs) regulate diverse cellular processes including proliferation, differentiation, survival, apoptosis, and migration.
  • MAPK pathways are activated by extracellular stimuli and mediate context-dependent cellular responses.
  • These signaling cascades are essential for normal physiological functions.

Purpose of the Study:

  • To elucidate the roles of MAPKs in cellular responses.
  • To investigate the non-redundant functions of different MAPK families.
  • To understand the integration of MAPK signaling in B cell receptor pathways and B cell-mediated immunity.

Main Methods:

  • Utilized genetically engineered mouse models to study MAPK functions.
  • Employed chemical inhibitors specific to individual MAPK signaling pathways.
  • Analyzed the impact of MAPK modulation on cellular processes and immune responses.

Main Results:

  • MAPKs exhibit diverse and non-redundant physiological roles across different families.
  • MAPK signaling pathways are integral components of the B cell receptor signaling network.
  • These pathways critically influence the activation and function of B cells in immunity.

Conclusions:

  • MAPKs are key regulators of cellular fate and function.
  • Distinct MAPK families possess unique and indispensable roles.
  • MAPK cascades are critical for orchestrating B cell-mediated immune responses.

More Related Videos

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants07:38

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants

Published on: June 6, 2025

922
Spatial and Temporal Analysis of Active ERK in the C. elegans Germline08:40

Spatial and Temporal Analysis of Active ERK in the C. elegans Germline

Published on: November 29, 2016

10.9K

Related Concept Videos

MAPK Signaling Cascades01:07

MAPK Signaling Cascades

Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
9.3K
Amplifying Signals via Enzymatic Cascade01:22

Amplifying Signals via Enzymatic Cascade

When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze...
19.5K
Intracellular Signaling Cascades01:24

Intracellular Signaling Cascades

Once a ligand binds to a receptor, the signal is transmitted through the membrane and into the cytoplasm. The continuation of a signal in this manner is called signal transduction. Signal transduction only occurs with cell-surface receptors, which cannot interact with most components of the cell, such as DNA. Only internal receptors can interact directly with DNA in the nucleus to initiate protein synthesis. When a ligand binds to its receptor, conformational changes occur that affect the...
55.3K
Intracellular Signaling Cascades01:24

Intracellular Signaling Cascades

37.3K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.9K
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
3.8K