Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mismatch Repair01:20

Mismatch Repair

7.1K
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
7.1K
Abnormal Proliferation02:23

Abnormal Proliferation

5.4K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Precision in RNA degradation: helicases, ribosome and RNA polymerase stalling, and RNA modifications.

Trends in cell biology·2026
Same author

Transposable element-gene chimera cartography, origination and role in enhancing transcriptome plasticity.

Nature structural & molecular biology·2026
Same author

A vasculature-resident innate lymphoid cell population in mouse lungs.

Nature communications·2025
Same author

Upper Respiratory Microbiome in Vasculitis.

Rheumatic diseases clinics of North America·2025
Same author

AID in non-Hodgkin B-cell lymphomas: The consequences of on- and off-target activity.

Advances in immunology·2024
Same author

Somatic hypermutation mechanisms during lymphomagenesis and transformation.

Current opinion in genetics & development·2024

Related Experiment Video

Updated: Apr 5, 2026

Rapid Analysis of Chromosome Aberrations in Mouse B Lymphocytes by PNA-FISH
07:54

Rapid Analysis of Chromosome Aberrations in Mouse B Lymphocytes by PNA-FISH

Published on: August 19, 2014

17.7K

Malaria-Induced B Cell Genomic Instability.

Gerson Rothschild1, A Nikolai von Krusenstiern1, Uttiya Basu1

  • 1Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, NY 10032, USA.

Cell
|August 16, 2015
PubMed
Summary
This summary is machine-generated.

Malaria infection in mice promotes genomic instability, mimicking key features of Burkitt lymphoma. This research explores the link between Plasmodium parasites and cancer development in endemic regions.

More Related Videos

CRISPR/Cas9 Gene Editing to Make Conditional Mutants of Human Malaria Parasite P. falciparum
09:25

CRISPR/Cas9 Gene Editing to Make Conditional Mutants of Human Malaria Parasite P. falciparum

Published on: September 18, 2018

10.7K
Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum
10:22

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Published on: December 4, 2015

9.4K

Related Experiment Videos

Last Updated: Apr 5, 2026

Rapid Analysis of Chromosome Aberrations in Mouse B Lymphocytes by PNA-FISH
07:54

Rapid Analysis of Chromosome Aberrations in Mouse B Lymphocytes by PNA-FISH

Published on: August 19, 2014

17.7K
CRISPR/Cas9 Gene Editing to Make Conditional Mutants of Human Malaria Parasite P. falciparum
09:25

CRISPR/Cas9 Gene Editing to Make Conditional Mutants of Human Malaria Parasite P. falciparum

Published on: September 18, 2018

10.7K
Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum
10:22

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Published on: December 4, 2015

9.4K

Area of Science:

  • Immunology
  • Oncology
  • Infectious Diseases

Background:

  • Burkitt lymphoma is a B-cell cancer prevalent in malaria-endemic regions.
  • Malaria, caused by Plasmodium parasites, is a major global health concern.
  • Genomic instability is a hallmark of many cancers, including Burkitt lymphoma.

Purpose of the Study:

  • To investigate the role of Plasmodium infection in driving genomic instability.
  • To explore the potential of Plasmodium-induced lymphomagenesis as a model for Burkitt lymphoma.
  • To understand the mechanisms linking parasitic infection to cancer development.

Main Methods:

  • Mice were infected with Plasmodium parasites.
  • Genomic instability was assessed in B cells.
  • Germinal center reactions and lymphomagenesis were analyzed.
  • Comparative analysis with Burkitt lymphoma characteristics was performed.

Main Results:

  • Plasmodium infection led to significant genomic instability in mice.
  • The study observed germinal center-derived lymphomagenesis.
  • Key features resembling Burkitt lymphoma were successfully recreated in the mouse model.

Conclusions:

  • Plasmodium infection can induce genomic instability and lymphomagenesis.
  • This mouse model provides insights into Burkitt lymphoma pathogenesis.
  • Understanding this link may inform strategies for cancer prevention in malaria-endemic areas.