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A proposed cascade of vascular events leading to granulomatous amoebic encephalitis

Abdul Mannan Baig1, Naveed Ahmed Khan2

  • 1Department of Biological and Biomedical Sciences, Aga Khan University, Pakistan.

Microbial Pathogenesis
|August 16, 2015
PubMed

Granulomatous amoebic encephalitis due to Acanthamoeba is a chronic disease that almost always results in death. Hematogenous spread is a pre-requisite followed by amoebae invasion of the blood-brain barrier to enter the central nervous system. Given the systemic nature of this infection, a significant latent period of several months before the appearance of clinical manifestations is puzzling. Based on reported cases, here we propose pathogenetic mechanisms that explain the above described latency of the disease.

Keywords:
AcanthamoebaBalamuthia mandrillarisGranulomatous amoebic encephalitisProtists

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