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Disorders of Leukocytes01:27

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Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
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Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
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Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
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Author Spotlight: Identification and Isolation of Quiescent Leukemia Stem Cells from Zebrafish T-ALL
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Author Spotlight: Identification and Isolation of Quiescent Leukemia Stem Cells from Zebrafish T-ALL

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T-lymphoblastic leukemia/lymphoma.

M James You1, L Jeffrey Medeiros2, Eric D Hsi3

  • 1From the Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston; and mjamesyou@mdanderson.org.

American Journal of Clinical Pathology
|August 16, 2015
PubMed
Summary
This summary is machine-generated.

Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a distinct subtype with poor prognosis. Recognizing ETP-ALL and other rare T-ALL/T-LBL entities is crucial for accurate diagnosis and targeted therapy.

Keywords:
Early T-cell precursorGeneticsImmunophenotypeT-ALL

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Area of Science:

  • Hematopathology
  • Oncology
  • Molecular Genetics

Background:

  • The 2013 Society for Hematopathology/European Association for Haematopathology Workshop focused on T-acute lymphoblastic leukemia/T-lymphoblastic lymphoma (T-ALL/T-LBL).
  • Understanding diagnostic and biologic features of T-ALL/T-LBL is critical for patient outcomes.

Purpose of the Study:

  • To review key concepts from the 2013 workshop on T-ALL/T-LBL.
  • To highlight important diagnostic and prognostic factors in T-ALL/T-LBL.

Main Methods:

  • Review of 21 submitted cases of T-ALL/T-LBL.
  • Emphasis on diagnostic and biologic features.
  • Supplemented with relevant literature citations.

Main Results:

  • Early T-cell precursor ALL (ETP-ALL) constituted approximately one-third of submitted cases and is associated with a poor prognosis.
  • A consensus immunophenotype for ETP-ALL recognition was developed.
  • Rare entities, including Philadelphia chromosome-positive T-ALL and T-ALL with MYC translocations, were presented.
  • Differential diagnostic challenges in T-ALL/T-LBL were illustrated.

Conclusions:

  • Molecular genetic analysis is increasingly important for T-ALL/T-LBL diagnosis and prognosis.
  • Current diagnostic standards include histopathology, immunophenotyping, cytogenetics, FISH, and clonality testing.
  • Future therapies may necessitate genetic abnormality assessment for targeted treatment approaches.