Related Experiment Video

Updated: Apr 5, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

5.4K

Coronary events in obese hemodialysis patients before and after renal transplantation

Jose Jayme G De Lima1, Luis Henrique W Gowdak1, Flavio J de Paula2

  • 1Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil.

Clinical Transplantation
|August 17, 2015
PubMed

Insights

Obesity negatively impacts kidney transplant recipients, increasing risks for heart events and death. However, obesity did not affect prognosis in hemodialysis patients despite more cardiovascular risk factors.

Area of Science:

  • Nephrology
  • Cardiology
  • Public Health

Background:

  • Obesity is a growing concern in patients with chronic kidney disease (CKD).
  • The impact of obesity on cardiovascular outcomes and mortality in hemodialysis (HD) and renal transplant (TX) patients remains incompletely understood.
  • Understanding these associations is crucial for managing high-risk patient populations.

Purpose of the Study:

  • To investigate the association between obesity (Body Mass Index [BMI] ≥30 kg/m²) and prognosis in hemodialysis and renal transplant patients.
  • To compare cardiovascular events and mortality rates between obese and non-obese patients in both HD and TX cohorts.
  • To identify whether obesity is an independent predictor of adverse outcomes in these populations.

Main Methods:

  • A retrospective study of 1696 patients, including 357 obese individuals, undergoing hemodialysis or renal transplantation.
  • Data collected included baseline characteristics, cardiovascular risk factors, and clinical end-points (coronary events, composite cardiovascular events, death).
  • Statistical analyses, including log-rank tests and hazard ratios (HR), were used to assess the impact of obesity on prognosis.

Main Results:

  • Obese HD patients exhibited higher rates of diabetes, dyslipidemia, and ischemic heart disease compared to non-obese HD patients, but prognosis was not significantly affected.
  • Obese TX patients had more dyslipidemia, angina, myocardial infarction, and elevated lipids than non-obese TX patients.
  • Obesity was independently associated with a significantly increased risk of coronary events (HR 2.55) and death (HR 1.52) in renal transplant recipients, but not in hemodialysis patients.

Conclusions:

  • In renal transplant recipients, obesity is a significant independent predictor of adverse cardiovascular events and mortality.
  • While obese hemodialysis patients present with more cardiovascular risk factors, obesity itself does not appear to worsen their prognosis.
  • These findings highlight the differential impact of obesity on outcomes in kidney disease patients and underscore the need for targeted management strategies post-transplantation.

Keywords:
chronic kidney diseasehemodialysisischemic heart diseaseobesityrenal transplantation

More Related Videos

Robot-Assisted Kidney Transplantation07:30

Robot-Assisted Kidney Transplantation

Published on: July 19, 2021

4.6K
Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension04:37

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

862

Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
709
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
815
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
579
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
1.8K
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
499
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
343