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Does Streptococcus mitis, a neonatal oropharyngeal bacterium, influence the pathogenicity of Pseudomonas aeruginosa?

Sijie Song1, Lizhong Du2, Jialin Yu1

  • 1Department of Neonatology, Children's Hospital of Chongqing Medical University, Chongqing, China; Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Medical University, Chongqing, China; Key Laboratory of Pediatrics in Chongqing, Chongqing Medical University, Chongqing, China; Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital, Chongqing Medical University, Chongqing, China.

Microbes and Infection
|August 17, 2015
PubMed

Insights

Streptococcus mitis enhances Pseudomonas aeruginosa biofilm formation and reduces the immune response. This highlights the significant role of non-pathogenic bacteria in biofilm infections.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Bacterial Interactions

Background:

  • Microbial communities within biofilms exhibit complex interactions, influencing pathogenicity.
  • Pseudomonas aeruginosa (P. aeruginosa) and Streptococcus mitis (S. mitis) are frequently found in neonatal endotracheal tube biofilms.

Purpose of the Study:

  • To investigate the interaction between P. aeruginosa and S. mitis in biofilm formation.
  • To determine the effect of S. mitis on P. aeruginosa's adhesion, biofilm development, and host immune response.

Main Methods:

  • Co-culture experiments to assess biofilm formation.
  • Analysis of bacterial adhesion.
  • Evaluation of immune response markers.

Main Results:

  • S. mitis significantly enhanced the adhesion and biofilm formation of P. aeruginosa.
  • S. mitis co-colonization attenuated the immune response typically induced by P. aeruginosa.

Conclusions:

  • Traditionally non-pathogenic bacteria like S. mitis play a crucial role in modulating pathogenic bacterial biofilms.
  • Understanding these interactions is vital for developing novel therapeutic strategies against biofilm-related infections.
Keywords:
Host bacteria interactionNewbornsPseudomonas aeruginosaStreptococcus mitisVentilator associated pneumonia

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