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Complete pathologic response as a prognostic factor for squamous cell carcinoma of the oropharynx
Damila Cristina Trufelli1, Leandro Luongo de Matos2, Thaiana Aragão Santana1
1Discipline of Oncology, Faculdade de Medicina do ABC, Santo André, SP, Brazil.
Introduction:
Chemoradiotherapy for squamous cell carcinoma of the oropharynx (SCCO) provides good results for locoregional disease control, with high rates of complete clinical and pathologic responses, mainly in the neck.
Objective:
To determine whether complete pathologic response after chemoradiotherapy is related to the prognosis of patients with SCCO.
Methods:
Data were prospectively extracted from clinical records of N2 and N3 SCCO patients submitted to a planned neck dissection after chemoradiotherapy.
Results:
A total of 19 patients were evaluated. Half of patients obtained complete pathologic response in the neck. Distant or locoregional recurrence occurred in approximately 42% of patients, and 26% died. Statistical analysis showed an association between complete pathologic response and lower disease recurrence rate (77.8% vs. 20.8%; p=0.017) and greater overall survival (88.9% vs. 23.3%; p=0.049).
Conclusion:
The presence of a complete pathologic response after chemoradiotherapy positively influences the prognosis of patients with SCCO.
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