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Primary Pleural Synovial Sarcoma Treated with Pazopanib
Arata Sugitani1, Kazuhisa Asai, Kazuya Kojima
1Department of Respiratory Medicine, Graduate School of Medicine, Osaka City University, Japan.
Internal Medicine (Tokyo, Japan)
|August 18, 2015
Summary
A rare pleural synovial sarcoma presented as a lung nodule. Despite chemotherapy and targeted therapy, the disease was refractory, leading to a poor prognosis.
Area of Science:
- Oncology
- Thoracic Surgery
- Pathology
Background:
- Synovial sarcoma is a rare soft tissue malignancy.
- Pleural involvement is an uncommon presentation of synovial sarcoma.
Observation:
- A 42-year-old woman presented with a 2 cm right lung nodule, chest pain, and breathlessness.
- Initial bronchoscopy was negative for malignancy, but symptoms progressed with nodule enlargement and pleural effusion.
- Video-assisted thoracic surgery revealed pleural synovial sarcoma.
Findings:
- The patient received doxorubicin-ifosfamide chemotherapy for pelvic metastasis.
- A transient partial response was followed by refractory disease relapse.
- Second-line pazopanib treatment was ineffective.
Implications:
- Pleural synovial sarcoma is an aggressive malignancy with a poor prognosis.
- This case highlights the diagnostic challenges and limited treatment options for advanced pleural synovial sarcoma.
- Further research into novel therapeutic strategies is warranted for this rare cancer.
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