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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
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Isolation of Murine Lymph Node Stromal Cells
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Antigen archiving by lymph node stroma: A novel function for the lymphatic endothelium.

Ross M Kedl1, Beth A Tamburini1

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Secondary lymphoid stromal cells actively shape T-cell responses. Lymphatic endothelial cells (LECs) capture and archive antigens, crucial for immune memory.

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Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Secondary lymphoid stroma provides more than structural support, influencing leukocyte trafficking and T-cell responses.
  • Stromal cells can directly stimulate T cells or indirectly manage antigens post-infection or vaccination.

Purpose of the Study:

  • To review stromal cell subsets and functions in adaptive immunity.
  • To emphasize antigen capture and retention by follicular dendritic cells and lymphatic endothelial cells (LECs).
  • To discuss the role of LECs in antigen archiving and its impact on immune memory.

Main Methods:

  • This is a review article, synthesizing existing research.
  • Focuses on analyzing data regarding stromal cell functions and antigen handling.

Main Results:

  • Stromal cells, including follicular dendritic cells and LECs, play active roles in antigen presentation and retention.
  • LECs exhibit a novel 'antigen archiving' function, influencing adaptive immune responses.

Conclusions:

  • Stromal cells are critical regulators of adaptive immunity and immune memory.
  • Further research is needed on LEC antigen capture, archiving, and exchange with antigen-presenting cells for maintaining protective immunity.