[Carcinogenicity and organic fraction of indoor inhalable particles]

The inhalable particles in high and low incidence area of lung cancer in Xuanwei country were extracted with dichloromethane. The extract was separated into aliphatics, PAH, N-PAH, H-PAH, polar compounds by neutral aluminum oxide column chromatography. Mutagenicity and carcinogenicity of different fraction were studied in the Ames test and Two-stage skin carcinogenesis test. The results suggested that the indoor air pollutants in high incidence area showed higher carcinogenicity, higher percentage of PAH fraction and methylated PAH. Ames test showed PAH, N-PAH, H-PAH were active fractions, the N-PAH fraction has maximal mutagenicity. Two-stage skin carcinogenesis test showed the PAH fraction has the highest carcinogenicity, followed by the N-PAH fraction. The results indicated the main carcinogenic fraction and carcinogens of indoor air pollutions in high incidence area of lung cancer in Xuanwei country.