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Neonatal Gabapentin Withdrawal Syndrome
Melisa Carrasco1, Sanjai C Rao2, Cynthia F Bearer3
1Department of Pediatrics, Children's Hospital, University of Maryland, Baltimore, Maryland.
Pediatric Neurology
|August 18, 2015
Summary
Gabapentin, used for various conditions, may cause withdrawal symptoms in newborns after maternal use during pregnancy. Gradual tapering of gabapentin in neonates is recommended to manage these potential effects.
Area of Science:
- Neurology
- Neonatal Medicine
- Pharmacology
Background:
- Gabapentin is a widely prescribed medication for epilepsy, bipolar illness, neuropathic pain, hyperemesis gravidarum, and restless leg syndrome.
- While generally considered safe during pregnancy, its effects on neonates are not fully documented.
Observation:
- This report details a case of a newborn exhibiting withdrawal symptoms.
- The neonate experienced these symptoms following prolonged in utero exposure to gabapentin.
Findings:
- Neonatal withdrawal syndrome can occur after maternal gabapentin exposure during pregnancy.
- Observed symptoms in the neonate indicated a potential adverse effect of prenatal gabapentin exposure.
Implications:
- Clinicians must be aware of potential gabapentin withdrawal symptoms in neonates born to mothers using the drug during pregnancy.
- Gradual tapering of gabapentin in neonates over weeks to months is advised, mirroring adult treatment protocols.
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