Recent Advancement in the Treatment of Cardiovascular Diseases: Conventional Therapy to Nanotechnology

Area of Science:

• Biomedical Science
• Nanotechnology
• Cardiology

Background:

• Cardiovascular disease (CVD) accounts for approximately 30% of global deaths, affecting the heart and blood vessels.
• Current CVD therapies face challenges including systemic toxicity and stent thrombosis, necessitating novel treatment approaches.
• Molecular and nanotechnology offer promising avenues for cellular-level biomedical interventions in cardiac therapy.

Purpose of the Study:

• To review recent molecular and nanotechnology advances for cardiovascular disease (CVD) therapy.
• To discuss challenges and potential solutions in myocardial tissue engineering and drug delivery.
• To highlight therapeutic substitutes for clinical trials in CVD treatment.

Main Methods:

• Review of recent literature on CVD risk factors, inflammation, and therapeutic modalities.
• Discussion of molecular aspects including stem cell therapy, gene delivery, and miRNA applications.
• Summary of nanoparticle-based drug delivery, nanocarriers for molecular imaging, and tissue engineering challenges.

Main Results:

• Nanotechnology and molecular approaches offer unique features for cardiac therapy.
• Various therapeutic modalities like stem cell therapy, gene delivery, and TF inhibitors are discussed.
• Nanoparticle drug delivery and nanocarriers for molecular imaging show potential.

Conclusions:

• Molecular and nanotechnology advancements present new therapeutic options for cardiovascular diseases.
• Addressing challenges in drug delivery and tissue engineering is crucial for clinical translation.
• These innovative strategies may lead to new drug registrations and improved patient outcomes.